Deepak B. Kalgutkar: search on Z-Library

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1

Reactive Drug Metabolites (KALGUTKAR:REACTIVE METAB. O-BK) || Pathways of Reactive Metabolite Formation with Toxicophores/-Structural Alerts

Kalgutkar, Amit S., Dalvie, Deepak, Obach, R. Scott, Smith, Dennis A.

Year:

2012

Language:

english

File:

PDF, 373 KB

english, 2012

2

Interactions of Nitrogen-Containing Xenobiotics with Monoamine Oxidase (MAO) Isozymes A and B: SAR Studies on MAO Substrates and Inhibitors

Kalgutkar, Amit S., Dalvie, Deepak K., Castagnoli,, Neal, Taylor, Timothy J.

Journal:

Chemical Research in Toxicology

Year:

2001

Language:

english

File:

PDF, 292 KB

english, 2001

3

Predicting Toxicities of Reactive Metabolite–Positive Drug Candidates

Kalgutkar, Amit S., Dalvie, Deepak

Journal:

Annual Review of Pharmacology

Year:

2015

Language:

english

File:

PDF, 1.01 MB

english, 2015

4

A fast and simple method of isomerization for the preparation of ammonium (14C)thiocyanate from (14C)thiourea

Sanjay P. Patil, Deepak B. Kalgutkar, Narath Jaychandran, V.K.P. Unny

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Year:

2007

Language:

english

File:

PDF, 68 KB

english, 2007

5

An improved procedure for the preparation of radiochemically pure [carbonyl-14C]diuron

Deepak B. Kalgutkar, Sanjay P. Patil, Narath Jayachandran, V. K. P. Unnv

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Year:

2007

Language:

english

File:

PDF, 142 KB

english, 2007

6

Reactive Drug Metabolites (KALGUTKAR:REACTIVE METAB. O-BK) || Bioactivation and Inactivation of Cytochrome P450 and Other Drug-Metabolizing Enzymes

Kalgutkar, Amit S., Dalvie, Deepak, Obach, R. Scott, Smith, Dennis A.

Year:

2012

Language:

english

File:

PDF, 307 KB

english, 2012

7

Reactive Drug Metabolites (KALGUTKAR:REACTIVE METAB. O-BK) || Role of Reactive Metabolites in Drug-Induced Toxicity - The Tale of Acetaminophen, Halothane, Hydralazine, and Tienilic Acid

Kalgutkar, Amit S., Dalvie, Deepak, Obach, R. Scott, Smith, Dennis A.

Year:

2012

Language:

english

File:

PDF, 195 KB

english, 2012

8

Reactive Drug Metabolites (KALGUTKAR:REACTIVE METAB. O-BK) || Role of Reactive Metabolites in Genotoxicity

Kalgutkar, Amit S., Dalvie, Deepak, Obach, R. Scott, Smith, Dennis A.

Year:

2012

Language:

english

File:

PDF, 532 KB

english, 2012

9

Reactive Drug Metabolites (KALGUTKAR:REACTIVE METAB. O-BK) || Retrospective Analysis of Structure-Toxicity Relationships of Drugs

Kalgutkar, Amit S., Dalvie, Deepak, Obach, R. Scott, Smith, Dennis A.

Year:

2012

Language:

english

File:

PDF, 184 KB

english, 2012

10

Biotransformation Reactions of Five-Membered Aromatic Heterocyclic Rings

Dalvie, Deepak K., Kalgutkar, Amit S., Khojasteh-Bakht, S. Cyrus, Obach, R. Scott, O'Donnell, John P.

Journal:

Chemical Research in Toxicology

Year:

2002

Language:

english

File:

PDF, 447 KB

english, 2002

11

Drug discovery for a new generation of covalent drugs

Kalgutkar, Amit S, Dalvie, Deepak K

Journal:

Expert Opinion on Drug Discovery

Year:

2012

Language:

english

File:

PDF, 707 KB

english, 2012

12

NADPH-Dependent Covalent Binding of [ 3 H]Paroxetine to Human Liver Microsomes and S-9 Fractions: Identification of an Electrophilic Quinone Metabolite of Paroxetine

Zhao, Sabrina X., Dalvie, Deepak K., Kelly, Joan M., Soglia, John R., Frederick, Kosea S., Smith, Evan B., Obach, R. Scott, Kalgutkar, Amit S.

Journal:

Chemical Research in Toxicology

Year:

2007

Language:

english

File:

PDF, 225 KB

english, 2007

13

Practical approaches to resolving reactive metabolite liabilities in early discovery

Dalvie, Deepak, Kalgutkar, Amit S., Chen, Weichao

Journal:

Drug Metabolism Reviews

Year:

2015

Language:

english

File:

PDF, 716 KB

english, 2015

14

Reactive Drug Metabolites (KALGUTKAR:REACTIVE METAB. O-BK) || Structural Alert and Reactive Metabolite Analysis for the Top 200 Drugs in the US Market by Prescription

Kalgutkar, Amit S., Dalvie, Deepak, Obach, R. Scott, Smith, Dennis A.

Year:

2012

Language:

english

File:

PDF, 925 KB

english, 2012

15

Evaluation of the 14C-urea breath test using indigenously produced 14C-urea capsules and a modified technique for trapping exhaled breath

Tiwari, Bijaynath P., Nistala, Srinivas, Patil, Sanjay P., Kalgutkar, Deepak P., Jaychandran, Narath, Chander, Harish, Basu, Sandip

Journal:

Nuclear Medicine Communications

Year:

2014

Language:

english

File:

PDF, 363 KB

english, 2014

16

A Comprehensive Listing of Bioactivation Pathways of Organic Functional Groups

Kalgutkar, Amit, Gardner, Iain, Obach, R., Shaffer, Christopher, Callegari, Ernesto, Henne, Kirk, Mutlib, Abdul, Dalvie, Deepak, Lee, Jae, Nakai, Yasuhiro, O'Donnell, John, Boer, Jason, Harriman, Shaw

Journal:

Current Drug Metabolism

Year:

2005

Language:

english

File:

PDF, 483 KB

english, 2005

17

[Methods and Principles in Medicinal Chemistry] Reactive Drug Metabolites (KALGUTKAR:REACTIVE METAB.) || Dealing with Reactive Metabolite-Positive Compounds in Drug Discovery

Kalgutkar, Amit S., Dalvie, Deepak, Obach, R. Scott, Smith, Dennis A.

Year:

2012

Language:

english

File:

PDF, 291 KB

english, 2012

18

[Methods and Principles in Medicinal Chemistry] Reactive Drug Metabolites (KALGUTKAR:REACTIVE METAB.) || Mitigating Toxicity Risks with Affinity Labeling Drug Candidates

Kalgutkar, Amit S., Dalvie, Deepak, Obach, R. Scott, Smith, Dennis A.

Year:

2012

Language:

english

File:

PDF, 253 KB

english, 2012

19

[Methods and Principles in Medicinal Chemistry] Reactive Drug Metabolites (KALGUTKAR:REACTIVE METAB.) || Role of Reactive Metabolites in Pharmacological Action

Kalgutkar, Amit S., Dalvie, Deepak, Obach, R. Scott, Smith, Dennis A.

Year:

2012

Language:

english

File:

PDF, 621 KB

english, 2012

20

[Methods and Principles in Medicinal Chemistry] Reactive Drug Metabolites (KALGUTKAR:REACTIVE METAB.) || Managing IADRs - a Risk-Benefit Analysis

Kalgutkar, Amit S., Dalvie, Deepak, Obach, R. Scott, Smith, Dennis A.

Year:

2012

Language:

english

File:

PDF, 163 KB

english, 2012

21

[Methods and Principles in Medicinal Chemistry] Reactive Drug Metabolites (KALGUTKAR:REACTIVE METAB.) || Intrinsically Electrophilic Compounds as a Liability in Drug Discovery

Kalgutkar, Amit S., Dalvie, Deepak, Obach, R. Scott, Smith, Dennis A.

Year:

2012

Language:

english

File:

PDF, 242 KB

english, 2012

22

[Methods and Principles in Medicinal Chemistry] Reactive Drug Metabolites (KALGUTKAR:REACTIVE METAB.) || Case Studies on Eliminating/Reducing Reactive Metabolite Formation in Drug Discovery

Kalgutkar, Amit S., Dalvie, Deepak, Obach, R. Scott, Smith, Dennis A.

Year:

2012

Language:

english

File:

PDF, 570 KB

english, 2012

23

[Methods and Principles in Medicinal Chemistry] Reactive Drug Metabolites (KALGUTKAR:REACTIVE METAB.) || Experimental Approaches to Reactive Metabolite Detection

Kalgutkar, Amit S., Dalvie, Deepak, Obach, R. Scott, Smith, Dennis A.

Year:

2012

Language:

english

File:

PDF, 189 KB

english, 2012

24

[Methods and Principles in Medicinal Chemistry] Reactive Drug Metabolites (KALGUTKAR:REACTIVE METAB.) || Bioactivation and Natural Products

Kalgutkar, Amit S., Dalvie, Deepak, Obach, R. Scott, Smith, Dennis A.

Year:

2012

Language:

english

File:

PDF, 335 KB

english, 2012

25

[Methods and Principles in Medicinal Chemistry] Reactive Drug Metabolites (KALGUTKAR:REACTIVE METAB.) || Origin and Historical Perspective on Reactive Metabolites

Kalgutkar, Amit S., Dalvie, Deepak, Obach, R. Scott, Smith, Dennis A.

Year:

2012

Language:

english

File:

PDF, 113 KB

english, 2012